Articles by Dr Kushnir:
The role of decongestants, cromolyn, guafenesin, saline washes, capsaicin, leukotriene antagonists, and other treatments on rhinitis.
Immunol Allergy Clin North Am. 2011 Aug;31(3):601-17. doi: 10.1016/j.iac.2011.05.008.
Treatment of rhinitis should be selected based on careful diagnosis.1 Clinical symptoms of allergic and nonallergic rhinitis are similar despite the significant difference
in underlying mechanisms.2,3 Most of the treatments reviewed in this article are available over the counter (OTC) Read more
Allergic Asthma: Symptoms and Treatment
Kushnir NM, Kaliner MA
WAO online resources
Asthma is truly a syndrome encompassing several disease entities/endotypes. The word asthma derives from the Greek word for panting, or breathlessness, and thus describes the primary symptom of this disease. Asthma is recognized as a complex condition with differences in severity, natural history..
Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism.
Brown JM, Nemeth K, Kushnir-Sukhov NM, Metcalfe DD, Mezey E.
Clin Exp Allergy. 2011 Apr;41(4):526-34. doi: 10.1111/j.1365-2222.2010.03685.x. Epub 2011 Jan 24. PMID: 21255158
Mast cells (MCs) have a central role in the induction of allergic inflammation, such as seen in asthma, and contribute to the severity of certain autoimmune diseases, such as rheumatoid arthritis. The mast cell thus represents an important inflammatory cell, and one which has resisted therapeutic attempts to alter its role in disease. Read more
Clinical correlates of blood serotonin levels in patients with mastocytosis.
Kushnir-Sukhov NM, Brittain E, Scott L, Metcalfe DD.
Eur J Clin Invest. 2008 Dec;38(12):953-8. doi: 10.1111/j.1365-2362.2008.02047.x. PMID: 19021721
Mastocytosis is a clonal disorder associated with an increased mast cell burden. We have recently demonstrated the ability of human mast cells to express and be activated through multiple serotonin receptors; to synthesize and release serotonin; and that mastocytosis patients may have abnormal serotonin levels. As serotonin has been implicated in the genesis of clinical symptoms found in association with some chronic diseases, we have now determined the whole blood serotonin levels in 29 patients diagnosed with mastocytosis, and correlated these levels with multiple clinical and laboratory parameters. Read more
Effects of gamma radiation on FcepsilonRI and TLR-mediated mast cell activation.
Soule BP, Brown JM, Kushnir-Sukhov NM, Simone NL, Mitchell JB, Metcalfe DD.
J Immunol. 2007 Sep 1;179(5):3276-86. PMID: 17709544
Ionizing gamma radiation has several therapeutic indications including bone marrow transplantation and tumor ablation. Among immune cells, susceptibility of lymphocytes to gamma radiation is well known. However, there is little information on the effects of gamma radiation on mast cells, which are important in both innate and acquired immunity. Read more
Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis.
Akin C, Scott LM, Kocabas CN, Kushnir-Sukhov N, Brittain E, Noel P, Metcalfe DD.
Blood. 2007 Oct 1;110(7):2331-3. Epub 2007 Jul 16. PMID: 17638853
Idiopathic anaphylaxis remains a perplexing disorder in which existing prophylactic therapy is inadequate. In this prospective study, we sought to determine whether patients with idiopathic anaphylaxis might have evidence for a clonal disorder of mast cells related to mastocytosis and for which novel targeted therapies might be considered. Read more
Human mast cells are capable of serotonin synthesis and release.
Kushnir-Sukhov NM, Brown JM, Wu Y, Kirshenbaum A, Metcalfe DD.
J Allergy Clin Immunol. 2007 Feb;119(2):498-9. Epub 2006 Oct 13.
Increased levels of mast cell–associated mediators, such as tryptase and histamine, have been reported in patients with mastocytosis. Recently, we observed abnormal levels of peripheral blood serotonin in a subset of patients with mastocytosis. Read more
5-hydroxytryptamine induces mast cell adhesion and migration.
Kushnir-Sukhov NM, Gilfillan AM, Coleman JW, Brown JM, Bruening S, Toth M, Metcalfe DD.
J Immunol. 2006 Nov 1;177(9):6422-32.
The neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) is implicated in enhancing inflammatory reactions of skin, lung, and gastrointestinal tract. To determine whether 5-HT acts, in part, through mast cells (MC), we first established that mouse bone marrow-derived MC … Read more
Silica-directed mast cell activation is enhanced by scavenger receptors.
Brown JM, Swindle EJ, Kushnir-Sukhov NM, Holian A, Metcalfe DD.
Am J Respir Cell Mol Biol. 2007 Jan;36(1):43-52. Epub 2006 Aug 10. PMID: 16902192
Inhalation of crystalline silica results in pulmonary fibrosis and silicosis. It has been suggested that mast cells play a role in these conditions. How mast cells would influence pathology is unknown. We thus explored mast cell interactions with silica. Read more
Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis.
Kushnir-Sukhov NM, Brittain E, Reynolds JC, Akin C, Metcalfe DD.
Int Arch Allergy Immunol. 2006;139(3):265-70. Epub 2006 Jan 30. PMID: 16449817
Mastocytosis is associated with a pathological increase in tissue mast cells. Associated skeletal problems include a decrease in bone density and pathological fractures. In order to explore the relationship between bone density and the severity of mastocytosis, 21 patients with mastocytosis who underwent dual-energy X-ray absorptiometry were entered into this study. Read more
Increase in extracellular glutatione peroxidase in plasma and lungs of mice exposed to hyperoxia.
Kim KK, Whitin JC, Sukhova NM, Cohen HJ.
Pediatr Res. 1999 Dec;46(6):715-21.
Extracellular glutathione peroxidase (E-GPx) is a selenium-dependent enzyme that can reduce hydrogen peroxide and phospholipid hydroperoxides. E-GPx is found in plasma and extracellular fluids such as bronchoalveolar lavage fluid. Because lung is one of the tissues that is capable of synthesizing and secreting E-GPx, the effect of exposure to hyperoxia on E-GPx in plasma and lung were studied in an injury model of hyperoxia exposure in adult mice. Read more