Articles by Dr Kushnir:

The role of decongestants, cromolyn, guafenesin, saline washes, capsaicin, leukotriene antagonists, and other treatments on rhinitis.

Kushnir NM

Immunol Allergy Clin North Am. 2011 Aug;31(3):601-17. doi: 10.1016/j.iac.2011.05.008.

Treatment of rhinitis should be selected based on careful diagnosis.1 Clinical symptoms of allergic and nonallergic rhinitis are similar despite the significant difference
in underlying mechanisms.2,3 Most of the treatments reviewed in this article are available over the counter (OTC) Read more

Allergic Asthma: Symptoms and Treatment

Kushnir NM, Kaliner MA

WAO online resources

Asthma is truly a syndrome encompassing several disease entities/endotypes. The word asthma derives from the Greek word for panting, or breathlessness, and thus describes the primary symptom of this disease. Asthma is recognized as a complex condition with differences in severity, natural history..

Read more

 

Bone marrow stromal cells inhibit mast cell function via a COX2-dependent mechanism.

Brown JM, Nemeth K, Kushnir-Sukhov NM, Metcalfe DD, Mezey E.

Clin Exp Allergy. 2011 Apr;41(4):526-34. doi: 10.1111/j.1365-2222.2010.03685.x. Epub 2011 Jan 24. PMID: 21255158

Mast cells (MCs) have a central role in the induction of allergic inflammation, such as seen in asthma, and contribute to the severity of certain autoimmune diseases, such as rheumatoid arthritis. The mast cell thus represents an important inflammatory cell, and one which has resisted therapeutic attempts to alter its role in disease. Read more

Clinical correlates of blood serotonin levels in patients with mastocytosis.

Kushnir-Sukhov NM, Brittain E, Scott L, Metcalfe DD.

Eur J Clin Invest. 2008 Dec;38(12):953-8. doi: 10.1111/j.1365-2362.2008.02047.x. PMID: 19021721

Mastocytosis is a clonal disorder associated with an increased mast cell burden. We have recently demonstrated the ability of human mast cells to express and be activated through multiple serotonin receptors; to synthesize and release serotonin; and that mastocytosis patients may have abnormal serotonin levels. As serotonin has been implicated in the genesis of clinical symptoms found in association with some chronic diseases, we have now determined the whole blood serotonin levels in 29 patients diagnosed with mastocytosis, and correlated these levels with multiple clinical and laboratory parameters.  Read more

Effects of gamma radiation on FcepsilonRI and TLR-mediated mast cell activation.

Soule BP, Brown JM, Kushnir-Sukhov NM, Simone NL, Mitchell JB, Metcalfe DD.

J Immunol. 2007 Sep 1;179(5):3276-86. PMID: 17709544

Ionizing gamma radiation has several therapeutic indications including bone marrow transplantation and tumor ablation. Among immune cells, susceptibility of lymphocytes to gamma radiation is well known. However, there is little information on the effects of gamma radiation on mast cells, which are important in both innate and acquired immunity. Read more

 

 

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis.

Akin C, Scott LM, Kocabas CN, Kushnir-Sukhov N, Brittain E, Noel P, Metcalfe DD.

Blood. 2007 Oct 1;110(7):2331-3. Epub 2007 Jul 16. PMID: 17638853

Idiopathic anaphylaxis remains a perplexing disorder in which existing prophylactic therapy is inadequate. In this prospective study, we sought to determine whether patients with idiopathic anaphylaxis might have evidence for a clonal disorder of mast cells related to mastocytosis and for which novel targeted therapies might be considered. Read more

 

Human mast cells are capable of serotonin synthesis and release.

Kushnir-Sukhov NM, Brown JM, Wu Y, Kirshenbaum A, Metcalfe DD.

J Allergy Clin Immunol. 2007 Feb;119(2):498-9. Epub 2006 Oct 13.

Increased levels of mast cell–associated mediators, such as tryptase and histamine, have been reported in patients with mastocytosis. Recently, we observed abnormal levels of peripheral blood serotonin in a subset of patients with mastocytosis. Read more

5-hydroxytryptamine induces mast cell adhesion and migration.

Kushnir-Sukhov NM, Gilfillan AM, Coleman JW, Brown JM, Bruening S, Toth M, Metcalfe DD.

J Immunol. 2006 Nov 1;177(9):6422-32.

The neurotransmitter serotonin (5-hydroxytryptamine (5-HT)) is implicated in enhancing inflammatory reactions of skin, lung, and gastrointestinal tract. To determine whether 5-HT acts, in part, through mast cells (MC), we first established that mouse bone marrow-derived MCRead more

Silica-directed mast cell activation is enhanced by scavenger receptors.

Brown JM, Swindle EJ, Kushnir-Sukhov NM, Holian A, Metcalfe DD.

Am J Respir Cell Mol Biol. 2007 Jan;36(1):43-52. Epub 2006 Aug 10. PMID: 16902192

Inhalation of crystalline silica results in pulmonary fibrosis and silicosis. It has been suggested that mast cells play a role in these conditions. How mast cells would influence pathology is unknown. We thus explored mast cell interactions with silica. Read more

Elevated tryptase levels are associated with greater bone density in a cohort of patients with mastocytosis.

Kushnir-Sukhov NM, Brittain E, Reynolds JC, Akin C, Metcalfe DD.

Int Arch Allergy Immunol. 2006;139(3):265-70. Epub 2006 Jan 30. PMID: 16449817

 Mastocytosis is associated with a pathological increase in tissue mast cells. Associated skeletal problems include a decrease in bone density and pathological fractures. In order to explore the relationship between bone density and the severity of mastocytosis, 21 patients with mastocytosis who underwent dual-energy X-ray absorptiometry were entered into this study. Read more

Increase in extracellular glutatione peroxidase in plasma and lungs of mice exposed to hyperoxia.

Kim KK, Whitin JC, Sukhova NM, Cohen HJ.

Pediatr Res. 1999 Dec;46(6):715-21.

Extracellular glutathione peroxidase (E-GPx) is a selenium-dependent enzyme that can reduce hydrogen peroxide and phospholipid hydroperoxides. E-GPx is found in plasma and extracellular fluids such as bronchoalveolar lavage fluid. Because lung is one of the tissues that is capable of synthesizing and secreting E-GPx, the effect of exposure to hyperoxia on E-GPx in plasma and lung were studied in an injury model of hyperoxia exposure in adult mice. Read more

Referenced articles:

Environ Health Perspect. 2019 Jan;127(1):17002. doi: 10.1289/EHP3523.
Prenatal Exposure to Select Phthalates and Phenols and Associations with Fetal and Placental Weight among Male Births in the EDEN Cohort (France).Philippat C1, Heude B2,3, Botton J4, Alfaidy N5, Calafat AM6, Slama R1; EDEN Mother–Child Cohort Study Group.

Environ Health. 2019; 18: 7.
Published online 2019 Jan 11. doi: 10.1186/s12940-018-0441-7
Trends in neonicotinoid pesticide residues in food and water in the United States, 1999–2015
Hillary A. Craddock at al

Environ Sci Pollut Res Int. 2015; 22: 5–34.
Published online 2014 Sep 19. doi: 10.1007/s11356-014-3470-y
Systemic insecticides (neonicotinoids and fipronil): trends, uses, mode of action and metabolites
N. Simon-Delso at al

PLoS One. 2019; 14(4): e0214787.
Published online 2019 Apr 4. doi: 10.1371/journal.pone.0214787
Neonicotinoid insecticide residues in subsurface drainage and open ditch water around maize fields in southwestern Ontario
Arthur W. Schaafsma at al

Gut. 2019 May 10. pii: gutjnl-2019-318427. doi: 10.1136/gutjnl-2019-318427. [Epub ahead of print]
Leaky gut: mechanisms, measurement and clinical implications in humans.
Camilleri M.

Adv Immunol. 2009;102:95-133. doi: 10.1016/S0065-2776(09)01202-4.  How the immune system achieves self-nonself discrimination during adaptive immunity.Jiang H1, Chess L.Author information

J Appl Physiol (1985). 2016 Mar 15; 120(6): 692–701.
Published online 2015 Sep 10. doi: 10.1152/japplphysiol.00536.2015
Molecular Adaptations to Exercise, Heat Acclimation, and Thermotolerance
Intestinal epithelial barrier function and tight junction proteins with heat and exercise
Karol Dokladny at al

Hong Kong Med J. 2017 Jun;23(3):291-5. doi: 10.12809/hkmj166189. Epub 2017 May 5.
Genetically modified foods and allergy.
Lee TH1, Ho HK2, Leung TF3.

Ann Agric Environ Med. 2013;20(3):413-9.
Benefits and risks associated with genetically modified food products.
Kramkowska M1, Grzelak T, Czyżewska K.

PLoS One. 2015 May 26;10(5):e0126926. doi: 10.1371/journal.pone.0126926. eCollection 2015.
Environmental mold and mycotoxin exposures elicit specific cytokine and chemokine responses.
Rosenblum Lichtenstein JH

Allergy Asthma Immunol Res. 2014 Nov;6(6):517-24. doi: 10.4168/aair.2014.6.6.517. Epub 2014 Sep 11.
Relationship between indoor air pollutant levels and residential environment in children with atopic dermatitis.
Lee JH

Sublingual immunotherapy for allergic rhinoconjunctivitis and asthma
 Clinical efficacy and immunological mechanisms of sublingual and subcutaneous immunotherapy in asthmatic/rhinitis children sensitized to house dust mite: an open randomized controlled trial.
 Sublingual immunotherapy for the treatment of allergic rhinoconjunctivitis and asthma: a systematic review.